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'I regret not discovering GLP-1s sooner,' says Oprah Winfrey

Oprah Winfrey credits GLP-1 medications with improving her relationship with food and regrets not using them since 2013, saying they ended years of sadness and shame.

Oprah Winfrey has expressed regret for not discovering GLP-1s and starting her weight loss journey sooner, which would have allowed her to arrive at the place she is now – a place of contentment with her weight and overall well-being. The former host of The Oprah Winfrey Show is on a press tour to promote her new book. She partnered with Dr. Ania M. Jastreboff for the book, Enough: Your Health, Your Weight and What It’s Like to Be Free. Accordin…
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Oprah Winfrey talked about her relapses with weight loss drugs and the “mental noise” that came back. What she said and why she continues treatment.

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Pajiba broke the news on Wednesday, January 14, 2026.
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