Mitochondrial Protein Deficiency Drives Increased Fat Intake and Obesity

Mitochondrial protein deficiency drives increased fat intake and obesity

Obesity is a global health concern that can contribute to diabetes, cardiovascular disease, and other metabolic disorders.

How Obesity Triggers Cellular Stress Through Unfolded Protein Response and

Obesity is often described as a disorder of excess fat accumulation, but a new review argues that this familiar definition misses the biological turmoil unfolding inside stressed cells. The condition is increasingly understood as a systemic disease in which overnutrition disrupts cellular quality-control systems, intensifies inflammation and generates damaging levels of reactive oxygen species (ROS). These changes can undermine the function of t…