Zurzuvae Research What Research on Zurzuvae Says The Sage Therapeutics and Biogen team completed two phase 3 trials on Zurzuvae before FDA approval. The SKYLARK trial included 196 women with severe PPD and evaluated changes to PPD symptoms as measured by the Hamilton Depression Rating Scale, a 17-item assessment designed to measure symptoms like mood, suicide risk, sleep, and anxiety. Women either took Zurzuvae or a placebo for 14 days, and wh…