Scientists Discover Proteins that Initiate Cellular Immunity in Bone Marrow

Scientists discover proteins that initiate cellular immunity in bone marrow

A researcher at the Hackensack Meridian Center for Discovery and Innovation (CDI) and physician-scientist colleagues from Hackensack Meridian Health have shown how a critical pathway is fundamental to the immune system.

HMH Specialists Uncover Key Pathway Triggering Cellular Immunity in CDI Lab

A groundbreaking study led by Hai-Hui “Howard” Xue, Ph.D., at the Hackensack Meridian Center for Discovery and Innovation (CDI) has illuminated critical early mechanisms directing T cell development in the immune system. This research, recently published in Science Immunology, elucidates how the transcription factors Tcf1 and Lef1 serve as gatekeepers at the inception of T cell lineage potential within hematopoietic progenitors, shedding unprece…