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Xylitol May Be Linked to Major Cardiovascular Events, Study Suggests
Researchers found a stepwise rise in cardiovascular events across blood xylitol levels in two cohorts of 17,710 adults.
New research found that people with the highest blood levels of xylitol had a 57 percent higher risk of major adverse cardiovascular events over six years compared to those with the lowest levels.
The National Institutes summarized research showing xylitol increases platelet sensitivity to clotting signals; blood levels rose roughly 1,000 fold within 30 minutes of consuming a xylitol sweetened beverage before returning to baseline.
In a second cohort followed for 30 years, the European Prospective Investigation into Cancer study in Norfolk, England, found an 18 percent increase; both cohorts were observational and cannot establish causality.
Full peer-reviewed publication of this specific analysis has not been announced, but Presenter Marco Witkowski of the University Hospital in Berlin said the findings highlight "how little we know about the cardiovascular safety of xylitol."
Xylitol remains an approved food additive in the United States, and no regulator has announced a review of the sweetener, which appears in sugar-free gum, mints, candies, and toothpaste.