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Weight-loss jabs can help you live longer

  • Novo Nordisk presented new data from the Select trial showing Wegovy, containing semaglutide, rapidly reduces heart attack, stroke, and death risk in high-risk overweight patients.
  • The randomized, double-blind Select trial enrolled 17,604 participants with established cardiovascular disease and obesity to assess semaglutide 2.4mg versus placebo for preventing cardiovascular events.
  • Analysis showed a 37% reduction in major cardiovascular events within three months and a 50% decrease in cardiovascular death within six months, with effects appearing before significant weight loss.
  • Lead author Dr. Jorge Plutzky stated semaglutide produced early treatment separation prior to full dosage or notable weight loss, and Professor Donna Ryan called the data definite proof of cardiovascular risk reduction.
  • These findings support early initiation of Wegovy in high-risk patients to reduce cardiovascular events, but further research is needed to clarify the mechanisms and confirm long-term benefits.
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Wegovy slashes heart disease risk ‘even before people shed weight’

Within six months, the drug reduced the risk of cardiovascular death by 50% and cut the risk of needing urgent treatment due to heart failure.

·London, United Kingdom
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Manchester Evening News broke the news in Manchester, United Kingdom on Monday, May 12, 2025.
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