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AAOS: GLP-1 Receptor Agonist Use Increases Five-Year Risk for Osteoporosis

Study of nearly 150,000 type 2 diabetes and obesity patients shows 29% higher osteoporosis and 12% higher gout risk over five years with GLP-1 receptor agonists.

Summary by Medical Xpress
Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for type 2 diabetes and obesity is independently associated with a significantly increased five-year risk for osteoporosis, gout, and osteomalacia compared with nonuse, according to a study presented at the annual meeting of the American Academy of Orthopaedic Surgeons, held from March 2 to 6 in New Orleans.

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Health broke the news in United States on Friday, March 6, 2026.
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