Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses

Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses

Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses IntroductionPrecision-cut lymph node slices (PCLNS) provide a physiologically relevant ex vivo model to investigate lymphoid immune activation and vaccine adjuvant function while preserving native tissue architecture. In this study, we established for the first time porcine PCLNS and assessed the immunostimulato…