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Foghorn to cut 40% of workforce after scrapping Lilly-partnered cancer drug

The biotech said the drug was safe but did not show enough benefit in Phase 1 testing, and the layoffs will leave about 65 employees.

  • On Thursday, Foghorn Therapeutics and Eli Lilly ended their oncology partnership, originally valued at up to $1.6 billion, prompting the Watertown, Massachusetts-based biotech to cut about 40% of its workforce.
  • Clinical data from the Phase 1 trial of cancer candidate FHD-909 failed to show sufficient efficacy, leading both companies to halt development and discontinue a separate selective SMARCA2 degrader program.
  • Foghorn's stock lost over 40% of its value following Thursday's announcement, opening at $2.08, while the company expects to record about $2.3 million in charges related to layoffs leaving it with about 65 employees.
  • Foghorn Chief Executive Officer Adrian Gottschalk stated the company will refocus resources on its proprietary portfolio, including potential treatments for blood cancer, prostate cancer, and an experimental oral inflammatory drug.
  • Restructuring is expected to extend Foghorn's cash runway into the second half of 2029; Citizens analyst Silvan Turkcan downgraded the stock to Market Perform, citing few visible catalysts ahead for remaining assets.
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Foghorn to cut 40% of workforce after scrapping Lilly

·London, United Kingdom
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WTVB broke the news on Thursday, October 1, 2026.
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