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Study Links Non-Brain Gene Variant to Anorexia Risk

Researchers found 17 of 154 anorexia patients carried rare PLIN4 variants, suggesting fat-storage pathways outside the brain may help drive disease risk.

Summary by Medical Xpress
A gene primarily active in fat and muscles could make a person more susceptible to anorexia nervosa, a deadly eating disorder with one of the highest mortality rates of any psychiatric disease.

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Researchers have found that patients with anorexia are nearly four times more likely to carry potentially harmful variants of a fat storage gene

·Madrid, Spain
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However, a new investigation opens a different way: part of the willingness to develop this disorder may be related to the way the body stores and uses fat.The finding points to a gene whose activity is concentrated mainly in adipose tissue and muscle, and not in the brain.The study, published in the scientific journal Frontiers in Psychiatry, has found an association between certain rare and potentially harmful variants of the PLIN4 gene and ne…

·Madrid, Spain
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Medical Xpress broke the news in Douglas, United Kingdom on Thursday, October 8, 2026.
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