Extreme trait values often have simpler genetic explanations than thought

Extreme trait values often have simpler genetic explanations than thought

Researchers at the Icahn School of Medicine at Mount Sinai have found evidence that people who fall at the extreme high or low ends of certain traits, such as cholesterol, blood glucose, height, and age at menopause, are more likely to have a simple genetic explanation than previously thought.

Rare Genetic Variants Drive Extreme Human Health Traits

Individuals occupying the far tails of complex health traits, such as cholesterol, blood glucose, age at menopause, and height, possess a fundamentally distinct genetic architecture.