The San Francisco 49ers travel to face the Seattle Seahawks on Sunday, October 11, 2026, with kickoff set for 4:25 PM EDT at Lumen Field. Dimers’ updated machine-learning models project a tight 25-23 Seahawks win. The prediction markets also have Seattle as the favorite, with Polymarket pricing the Seahawks at 60¢ and the 49ers at 41¢, and Kalshi giving Seattle a 58% chance to win.