Published 2 months ago

Empty-handed neurons might cause neurodegenerative diseases

Summary by Eurek Alert

Tokyo, Japan – Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer’s. They used fruit flies to show that depletion of mitochondria in axons can directly lead to protein accumulation. At the same time, significantly high amounts of a protein called eIF2β were found. Restoring the levels to normal led to a recovery in protein recycling. Su…

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Empty-handed neurons might cause neurodegenerative diseases

2 months ago·Washington, United States

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Sci Tech Daily

Mitochondrial Meltdown: The Energy Failure Behind Neurodegenerative Diseases

Key pathway identified for how depletion of axonal mitochondria disrupts autophagy. Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer’s. They used fruit flies to show that depletion of

3 months ago

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