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Eli Lilly Teams Up With Two Biotechs To Target Autoimmune Disease, Hearing Loss In Deals Worth $3 Billion - Eli Lilly and Co (NYSE:LLY)

  • On Wednesday, Eli Lilly announced an agreement with Germany-based Seamless Therapeutics to develop hearing loss treatments, marking Seamless's first major pharma partnership and expanding Lilly's hearing loss pipeline.
  • Seamless's leaders say talks that began in or before 2024 prompted Lilly to approach Seamless about its recombinase technology, reflecting Lilly's recent investments including the $700 million Institute for Genetic Medicine.
  • Seamless's platform uses recombinases that cut and rejoin DNA directly, enabling large, precise insertions independent of cellular repair, with enzyme discovery shortened to six months via directed evolution in bacteria.
  • Under the deal, Seamless Therapeutics will design site-specific recombinases and grant Eli Lilly an exclusive license while the latter advances candidates through development and commercialization, with Seamless eligible for more than $1.12 billion in payments excluding royalties.
  • Lilly's existing AK-OTOF program complements a competitive field including Regeneron and Sensorion, while Seamless Therapeutics aims to identify its first development candidate in 2026 and expand Lexington, MA offices.
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Handelsblatt broke the news in Düsseldorf, Germany on Wednesday, January 28, 2026.
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