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Daily Orange Juice May Shift Gene Activity Tied to Heart Health
A study found daily intake of two cups of 100% orange juice altered activity in over 1,700 genes linked to inflammation, blood vessel function, and metabolism.
- On Wednesday, Nov. 19, 2025, researchers from Brazil and the United States reported that 20 adults drinking around two cups of 100% orange juice daily for two months altered activity in over 1,700 genes, published in Molecular Nutrition & Food Research.
- Researchers suggested the mechanism involved flavonoids, natural antioxidants, and the project received funding from São Paulo Research Foundation, Brazil’s National Council for Scientific and Technological Development, the Food Research Center, and the U.S. Department of Agriculture’s National Institute of Food and Agriculture.
- Comparing participants by weight, researchers observed gene responses varied, with normal-weight participants showing reduced inflammation shifts and overweight participants showing changes linked to fat metabolism and blood pressure pathways.
- Despite molecular signals, researchers cautioned the very small study lacked a comparison drink, so it cannot prove orange juice alone caused the changes, while Nicolette Pace said it fits a healthy diet in moderation.
- If confirmed in larger trials, daily intake of 100% orange juice may support heart and metabolic health and reinforce the therapeutic potential of OJ by revealing molecular mechanisms.
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Leaning Left6Leaning Right1Center3Last UpdatedBias Distribution60% Left
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L 60%
C 30%
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