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Scientists Identify Trigger of Crohn’s Scarring, Research Suggests
The findings point to immune and endothelial cell interactions that may help researchers develop treatments aimed at scarring, not just inflammation.
- University of Edinburgh-led researchers identified specific immune cell clusters that stimulate excess scar tissue production in Crohn's disease, revealing biological pathways potentially driving fibrosis in the bowel wall.
- Crohn's disease causes persistent digestive tract inflammation, often leading to fibrosis where excess collagen builds up in the bowel wall; surgery currently remains the only option to clear blockages.
- Dr. Michael Glinka, research fellow at the University of Edinburgh, and his team used single-cell RNA sequencing and traditional pathology to confirm these cellular interactions, publishing findings in The Journal of Pathology.
- Understanding these cellular mechanisms offers hope for developing therapies that prevent or slow fibrosis, aiming to treat lasting damage rather than just inflammation.
- Maureen Dalgleish, 65-year-old retired teacher diagnosed in 1988, donated tissue to the study and described the research as a "complete game-changer" for those living with the condition.
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StvRetired teacher with Crohn’s says new research could be ‘game-changer’
Maureen Dalgleish has had Crohn’s disease for nearly 40 years. A retired primary school teacher who has had four surgeries due to Crohn’s disease has said new research into the condition could be a “complete game-changer”. Maureen Dalgleish, 65, was first diagnosed with Crohn’s disease in 1988, aged 28. Since then, she has surgery four times – in 2001, 2006, 2013 and 2025 – to manage fibrosis in her bowel, related to the condition. She has also …
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Scientists identify trigger of Crohn’s scarring, research suggests
Researchers hope the findings could lead to the development of new treatments.
·London, United Kingdom
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Total News Sources10
Leaning Left6Leaning Right0Center1Last UpdatedBias Distribution86% Left
Bias Distribution
- 86% of the sources lean Left
86% Left
L 86%
14%
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