Comprehensive genetic map offers new hope for tuberculosis treatments

Genetic interaction map could lead to better antibiotic pairings for tuberculosis

Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB). The unprecedented map reveals thousands of previously unknown genetic relationships, offering a new window into the inner workings of one of the world's deadliest pathogens.

Comprehensive genetic map offers new hope for tuberculosis treatments

Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB).

Systematic Genetic Mapping Opens New Doors for Tuberculosis Drug Discovery

Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB).

New study of bacterial genome could lead to better TB drugs

Rockefeller researchers created the first comprehensive map of interactions among genes essential to the survival of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. To enable the study, the team refined a CRISPRi-based platform they initially developed for tuning gene expression, extending it to support large-scale perturbation of gene pairs. Their platform has already revealed four new synergistic drug combinations and p…