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Common Painkillers Ibuprofen and Paracetamol Found to Fuel Antibiotic Resistance

Research by the University of South Australia shows ibuprofen and paracetamol increase genetic mutations in E. coli, raising antibiotic resistance risks including to ciprofloxacin, impacting global health.

  • University of South Australia researchers found ibuprofen and paracetamol increased mutations in Escherichia coli, reducing ciprofloxacin effectiveness and making the bacteria highly resistant.
  • Elderly individuals in long-term care facilities face increased risks from polypharmacy, while the World Health Organization classifies antimicrobial resistance as a global health threat causing 1.27 million deaths in 2019.
  • Laboratory analysis revealed the study assessed nine medications commonly used in residential aged care and found Advil and Tylenol increased mutation frequency by up to 12-fold.
  • Researchers caution that patients and prescribers should be mindful of dosing painkillers with antibiotics to avoid worsening resistance and reassess residential aged care prescribing practices.
  • The researchers at the University of South Australia call for expanded studies on drug interactions in patients on long-term regimens and urge global surveillance frameworks to include non-antibiotic drug data.
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Svenska DagbladetSvenska Dagbladet
+2 Reposted by 2 other sources
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Over-the-counter painkillers such as ibuprofen and paracetamol help bacteria outsmart antibiotic treatment, new research shows.

·Stockholm, Sweden
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scimex.org broke the news in on Tuesday, August 26, 2025.
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