Common medicines may influence CRISPR therapy outcomes and precision cancer treatment

CRISPR and Precision Cancer Therapy Efficacy Influenced by Common Drugs

A large analysis of thousands of FDA-approved drugs carried out at the Max Planck Institute for Evolutionary Anthropology in Leipzig shows that a number of commonly used drugs can influence the efficacy of CRISPR-based gene editing therapies. In addition, the researchers showed two proteins, estrogen receptor 2 (ESR2) and aldehyde oxidase 1 (AOX1) play an important role in the DNA repair pathway and identified some drugs that could potentially b…

Common medicines may influence CRISPR therapy outcomes and precision cancer treatment

15.12.2025 - Large-scale drug atlas uncovers new genome editing modulators and potential therapeutic strategies for DNA repair-deficient cancers. A comprehensive catalog of drug-DNA repair interactions: The study describes how more than 2,000 approved pharmaceuticals influence genome editing outcomes, creating a valuable resource for translational and therapeutic applications.