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Gilead's Trodelvy, with Keytruda, cuts breast cancer risk by 35% in trial

  • Gilead Sciences and Merck reported on May 31, 2025, that combining Trodelvy with Keytruda reduces tumor progression risk in aggressive triple-negative breast cancer patients.
  • This aggressive breast cancer subtype lacks common biomarkers and has limited treatment options, prompting evaluation of new therapies like Trodelvy and Keytruda.
  • In a large trial with a 14-month median follow-up, patients receiving the combination experienced 11.2 months progression-free survival, compared to 7.8 months with chemotherapy and Keytruda.
  • The combination lowered tumor progression risk by 35% and extended median response duration to 16.5 months versus 9.2 months for chemotherapy patients, according to data presented at ASCO.
  • Experts expect these findings to reshape treatment standards for advanced triple-negative breast cancer, making the combination a likely new frontline option despite some risks like neutropenia.
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Gilead's Trodelvy, with Keytruda, cuts breast cancer risk by 35% in trial

The data may change how patients are treated following a diagnosis for advanced triple-negative breast cancer, one expert said.

·United Kingdom
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The Mighty 790 KFGO broke the news in on Saturday, May 31, 2025.
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