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Christina Applegate tested for lupus and Lyme disease

Doctors are testing for other illnesses that can mimic multiple sclerosis as Applegate says she still has fatigue, pain and limited mobility.

  • On Tuesday, actress Christina Applegate revealed she is undergoing medical testing for lupus and Lyme disease as doctors search for answers following her recent multiple sclerosis misdiagnosis.
  • The 54-year-old actress spent five years battling symptoms she believed were caused by MS, only to learn last month that the diagnosis was incorrect, leaving her without explanation for her condition.
  • During the November 3 episode of her "MeSsy" podcast co-hosted with The Sopranos star Jamie-Lynn Sigler, Christina explained she is investigating "sister diseases" to MS, stating "I'm being tested for all that stuff, slowly but surely."
  • Admitting she feels like a "fraud" after six years living with the MS identity, Christina said she remains in pain and continues struggling with daily mobility, still requiring a walker for household tasks.
  • Despite the ongoing health mystery, the actress confirmed she will remain involved with the MS community, emphasizing she intends to continue supporting friends she made during her diagnosis journey "in one way or another.
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Christina Applegate lived for several years in the assumption of suffering from multiple sclerosis. After it turned out that it was a misdiagnosis, the actress feels like a "fraudress," as she suggests.

·Berlin, Germany
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TMZ broke the news in Burbank, United States on Tuesday, November 3, 2026.
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