Chimpanzee stem cells offer new insights into early embryonic development

Comparative characterization of human accelerated regions in neurons

Human accelerated regions (HARs) are conserved genomic loci that have experienced rapid nucleotide substitutions following the divergence from chimpanzees1,2. HARs are enriched in candidate regulatory regions near neurodevelopmental genes, suggesting their roles in gene regulation3. However, their target genes and functional contributions to human brain development remain largely uncharacterized. Here we elucidate the cis-regulatory functions of…

Chimpanzee stem cells offer new insights into early embryonic development

Understanding how cells differentiate during early embryonic development is crucial for advancing regenerative medicine and developmental biology. Pluripotent stem cells (PSCs) have been invaluable tools in this field, as they can transform into various cell types in the body and play key roles during early embryonic development. Unfortunately, research on this topic in humans and other primates has long been hampered by ethical constraints and …

Chimpanzee Stem Cells Shed Light on Early Embryonic Development

Unlocking the Secrets of Chimpanzee Naive Pluripotent Stem Cells: A Leap Forward in Developmental Biology Understanding the intricate processes by which cells differentiate during the earliest stages of embryonic development holds immense promise for the fields of regenerative medicine and developmental biology. Pluripotent stem cells (PSCs), celebrated for their ability to give rise to any cell type within the body, have become indispensable in…