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CDC Warns on Rise in Deadly Fungal Infections That Spread to the Brain

Researchers said 48 confirmed cases and one probable case were identified from 2009 to 2026, with infection rates rising as high as 70% fatality.

  • Last week, the U.S. Centers for Disease Control and Prevention reported a fourfold increase in detections of the rare brain fungus Cladophialophora bantiana between 2023 and 2025.
  • C. bantiana typically causes deadly brain abscesses with a mortality rate between 60% and 70% even with treatment, targeting the central nervous system in 88% of cases.
  • University of Washington researchers identified 48 confirmed and one probable case across 21 states and the District of Columbia between January 2009 and July 2026.
  • Healthcare providers should consider C. bantiana when treating unexplained brain abscesses, requiring prompt surgical intervention paired with combination antifungal therapy for optimal survival chances.
  • Though the cause remains unclear, researchers note the infection affects healthy people and suggest climate change or environmental factors could contribute to rising detections.
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MedPage Today broke the news in New York, United States on Monday, October 5, 2026.
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