Catching cancer's earliest moments: How mutated cells transform their local environment so a tumor can develop

Catching cancer's earliest moments: How mutated cells transform their local environment so a tumor can develop

Scientists at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues are shedding new light on a tumor's earliest moments—revealing how lung cells with cancer-causing mutations recruit accomplices from healthy surrounding tissue to pave the way for a tumor to develop.

Early Fibrotic Niches Establish Tumor-Permissive Microenvironments

Using integrated single-cell, spatial, and functional analyses, scientists defined the earliest multicellular events that license this transition following oncogenic activation in the lung. [Nature] Full Article

Earliest Events of Lung Cancer Development Mapped

Researchers at Memorial Sloan Kettering (MSK) Cancer Center have identified the earliest cellular and molecular events that create the needed conditions for lung cancer cells to begin their growth into a tumor. The study, published in Nature, describes how cells with cancer-causing mutations initiate a coordinated chain of events to involve nearby fibroblasts and immune cells to create a microenvironment conducive to tumor growth at the very sta…