US EditionY Chromosome Loss Linked to Poor Cancer Outcomes
- A June 4, 2025, study led by Dan Theodorescu in Nature demonstrated that when both cancer cells and T cells in male patients lack the Y chromosome, it leads to poorer cancer outcomes.
- The study originated from Theodorescu's earlier observations at Cedars-Sinai and was further developed with collaborator Simon Knott to explore how Y chromosome loss affects immune and cancer cells.
- They found that Y chromosome loss occurs not only in malignant epithelial cells but also in helper and cytotoxic T cells, impairing immune response and fostering more aggressive tumors.
- According to Theodorescu, “If you put those two together, that's really bad,” as LOY in both cell types creates a "vicious cycle" of chromosomal aberrations and immune dysfunction that reduces survival.
- These findings imply that screening for Y chromosome loss in immune cells might improve immunotherapy effectiveness and guide development of tailored treatments to increase men's cancer survival rates.
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12 Articles
Arizona study finds missing Y chromosome may help explain why some cancer treatments work less in men
TUCSON, Ariz. — A University of Arizona study has found that men who lose the Y chromosome in their blood cells may respond less effectively to cancer treatments, offering new insight into why they often face worse outcomes than women.
Y chromosome loss linked to poor cancer outcomes
When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according to new findings from Cedars-Sinai investigators.
Study shows loss of Y in blood cells hinders immune response to cancer
A study initiated by a University of Arizona Comprehensive Cancer Center physician-scientist defined for the first time how loss of the Y chromosome in male immune cells negatively affects immune system function, which may explain why loss of Y is associated with lower cancer survival rates.
Loss of Y Chromosome Leads to Poor Cancer Outcomes (Cedars Sinai Medical Center)
) When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according to new findings from Cedars-Sinai investigators. Their work, published in the scientific journal Nature, could lead to ways to make some cancer treatments more effective. The Y chromosome is one of two chromosomes that determine biological sex in mam…
Cancer more deadly when tumours lack Y chromosomes — and the loss could be contagious
Losing the Y chromosome seems to make cancer cells more aggressive in men and the phenomenon may even spread between cells. Losing the Y chromosome seems to make cancer cells more aggressive in men and the phenomenon may even spread between cells.
Men with cancer are at greater risk than previously thought - Loss of the Y chromosome reduces their chances of recovery.
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