Alcohol and Medication Does Alcohol Interact With Breast Cancer Medications? Drinking alcohol while undergoing treatment for metastatic breast cancer, including chemotherapy and hormone therapy like tamoxifen and aromatase inhibitors, can cause liver strain and even affect how these drugs work, Khan says. “It is important to note that many medications are metabolized by the liver, which also metabolizes alcohol,” says Katie McLean, RDN, a seni…