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Lipocine Presents LPCN 2401 Clinical Data at ObesityWeek®

  • A Phase Ib study of ASC30 oral tablet showed a mean body weight reduction of up to 6.5% compared to placebo, with mild-to-moderate gastrointestinal adverse events reported.
  • The Phase Ib study of ASC30 subcutaneous injection revealed half-lives of 46 days for Injection A and 75 days for Injection B.
  • The combination of ASC47 and ASC31 significantly outperformed tirzepatide and ASC31 monotherapy in promoting weight loss and muscle preservation in diet-induced obesity mouse studies.
  • Presentations emphasized the promising efficacy and safety profiles of Ascletis' obesity pipeline and validated their Artificial Intelligence-Assisted Structure-Based Drug Discovery and Ultra-Long-Acting Platform technologies.
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Kingsport Times-NewsKingsport Times-News
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Ascletis Presents Full Analysis of Phase Ib Study of ASC30 Oral Tablet, Phase Ib Study of ASC30 Injection, and Preclinical Study of Combination of ASC31 and ASC47 at ObesityWeek® 2025

Positive data from Phase Ib study of ASC30 oral tablet demonstrated up to 6.5% placebo-adjusted mean body weight reduction; safe and well tolerated with only mild-to-moderate gastrointestinal (GI) adverse events (AEs) across all multiple ascending dose (MAD) cohorts.

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PR Newswire broke the news in United States on Tuesday, November 4, 2025.
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