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Popular Sugar Substitute Linked to Brain Cell Damage and Stroke Risk

BOULDER COUNTY, COLORADO, JUL 18 – The study found erythritol impairs brain vascular cells by increasing oxidative stress and altering clotting signals, potentially raising stroke risk, supported by data from 4,000 U.S. and European participants.

  • New laboratory research reveals the non-nutritive sweetener erythritol impairs brain microvascular endothelial cell function, published in the Journal of Applied Physiology.
  • Non-Nutritive sweeteners such as erythritol have become popular, with growing evidence linking them to adverse vascular effects, raising health concerns.
  • In a lab experiment, human brain microvascular endothelial cells showed impaired regulation of blood flow, reduced nitric oxide production, and increased oxidative stress, as the study reports.
  • Experts cautioned, `Our study adds to the evidence suggesting that non-nutritive sweeteners that have generally been purported to be safe, may not come without negative health consequences,` said Christopher DeSouza.
  • Highlighting research gaps, study authors caution that their cell-based findings require larger in vivo studies to assess long-term effects.
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Sci Tech Daily broke the news in on Friday, July 18, 2025.
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