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AI Review of 410,000 Reddit Posts Flags Period Changes and Chills Not Fully Captured in GLP-1 Trials

Summary by Medical Daily
A Penn study used AI to analyze 410,198 Reddit posts about semaglutide and tirzepatide. It flagged menstrual and temperature symptoms but cannot show cause.

4 Articles

Changes in menstrual cycles, hot flashes, chills, and chronic fatigue are just some of the symptoms increasingly reported by people taking popular medications for type 2 diabetes and obesity, such as Ozempic. Recent research shows that the list of possible side effects may be much longer than previously thought. Scientists have analyzed hundreds of thousands of online posts and discovered disturbing signals that could impact the health of millio…

Menstrual cycle changes, hot flashes, chills and fatigue are among the side effects reported by people taking GLP-1 receptor agonists that may be under-reported in clinical trials and official information, Nature Health reports.

Analysis of hundreds of thousands of online posts has revealed conditions that may be insufficiently covered in official information about GLP-1 drugs. This could be an important complement to traditional methods of monitoring drug safety.

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Medical Daily broke the news on Tuesday, September 15, 2026.
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