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AI-Designed COVID Vaccine Passes First Human Trial

The needle-free DNA shot was safe in 39 volunteers and triggered immune responses to SARS-CoV-2, SARS and related bat viruses.

  • Researchers at the University of Cambridge and DIOSynVax developed an AI-designed 'super-antigen' vaccine offering protection against entire families of viruses rather than just specific strains.
  • Artificial intelligence analyzed genetic codes from various coronaviruses to identify essential, unchanging elements across virus families, creating a 'fundamentally new' approach that future-proofs against mutations.
  • A phase I trial in Cambridge and Southampton involving 49 healthy volunteers aged 18 to 50 confirmed the vaccine is safe and triggered immune responses against SARS-CoV-2, SARS, and related bat viruses.
  • More than 200 individuals will be recruited for a forthcoming phase II study, with Professor Jonathan Heeney calling the technology a 'game changer' for vaccine development.
  • Scientists are now exploring applications for other virus families, including Ebola and bird flu, aiming to prevent pandemics before they start and potentially save millions of lives.
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Center

Researchers at the University of Cambridge have tested an AI-developed vaccine on humans for the first time – it is intended to protect against entire virus families.

Lean Left

Medical science has taken a historic step in the prevention of global health crises, as a team of researchers from Cambridge University developed a “essentially new” vaccine using artificial intelligence (AI). This drug promises to act proactively against all known variants of the coronavirus and anticipate future mutations before they jump from animals to humans.

Lean Left

A team of British researchers, led by scientists from the Universities of Cambridge and Southampton in the United Kingdom, has developed the first vaccine, completely developed by artificial intelligence, to be tested on humans.

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The Independent broke the news in London, United Kingdom on Thursday, June 4, 2026.
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