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How Do These ADHD Medications Work in the Brain? The Mechanisms Are Different Than Once Thought, a Study Suggests

Study of 5,795 children finds stimulants raise arousal and motivation by activating reward and wakefulness brain centers, aiding ADHD and sleep-deprived children’s performance.

Summary by Smithsonian Mag
Adderall, Ritalin and other stimulants prescribed for attention-deficit/hyperactivity disorder seem to work on brain areas involved with wakefulness and reward, rather than attention

5 Articles

A brain study involving nearly 6,000 children suggests that drugs often used to treat attention deficit hyperactivity disorder, such as Ritalin and amphetamines, do not directly improve the brain's ability to focus, but instead affect the functioning of brain regions related to wakefulness and the reward system.

·Estonia
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Hospital News broke the news in on Tuesday, December 30, 2025.
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