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A universal 'instruction manual' helps immune cells protect our organs

The transcription factor MafB regulates macrophage maturation and function, with its absence causing organ defects, a process conserved across vertebrates, researchers report.

Summary by Medical Xpress
Researchers at the University of Liège have identified a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs. The MafB factor, a veritable "molecular switch," activates or deactivates certain genes at the right time and in the right place, leading to the production of macrophages responsible for defending our body and supporting the functioning of our organs. Without MafB, macrophages can b…

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Sci Tech Daily broke the news in on Thursday, February 26, 2026.
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