A Quick Squeeze Helps CRISPR Turn Skin Cells Into Neurons More Efficiently

A quick squeeze helps CRISPR turn skin cells into neurons more efficiently

Human cells hold about two meters (6.6 feet) of DNA, folded and compacted to fit inside a nucleus. That packing is essential for life, but it creates a problem for scientists. Some of the genes that control a cell's identity are buried so deep in tightly packed DNA that gene-targeting tools such as CRISPR activation, or CRISPRa, struggle to reach them.