A Physiology Based Three Layer Diffusion Reaction Model For In Vitro To In Vivo Translation Of Intravesical Mitomycin C Exposure In The Human Urinary Bladder Wall

A Physiology Based Three Layer Diffusion Reaction Model For In Vitro To In Vivo Translation Of Intravesical Mitomycin C Exposure In The Human Urinary Bladder Wall

Intravesical mitomycin C reduces recurrence after resection of non-muscle-invasive bladder cancer, but response varies widely between patients, and dose, instillation volume, and dwell time are still chosen empirically. The concentration reached within the wall should govern those choices, but...