A drug may help people on GLP-1 meds preserve muscle
In a 102-person trial, apitegromab cut lean-mass loss by about 1.9 kg while overall weight loss stayed similar, researchers said.
- On Monday, June 8, 2026, researchers published a study in Nature Medicine showing that experimental antibody apitegromab helps preserve lean muscle mass during weight loss when taken alongside tirzepatide.
- Weight-Loss injections like Mounjaro, which contains tirzepatide, often cause rapid fat reduction alongside significant loss of lean muscle mass, negatively impacting strength and metabolic health.
- Led by Richard Pratley of the AdventHealth Translational Research Institute, a 24-week trial of 102 adults found apitegromab participants lost 14.6% lean mass versus 30.2% in the placebo group.
- Dr. Marie Spreckley of Cambridge University described the findings as "encouraging early evidence," though she noted the study did not demonstrate clear improvements in physical function or long-term outcomes.
- Apitegromab is not currently approved by the U.S. Food and Drug Administration and is available only via intravenous infusion, making it inaccessible to the general public for now.
12 Articles
12 Articles
Muscle Drug Cuts Lean Mass Loss From Slimming Jabs, Study Finds
Slimming jabs like Wegovy and Mounjaro have been hailed as game-changers for weight loss. But here’s the catch — what if you’re losing more than just fat?Researchers say that while GLP-1 drugs are highly effective for shedding weight. Around 25–40% of that loss can come from lean body mass — meaning muscle. And that matters. Why? Because muscle isn’t just about strength. It helps burn calories and supports overall metabolic health.Now, a new ear…
Drug Fights GLP-1 Muscle Loss; Unapproved Retatrutide Prescriptions; Protein Swap
(MedPage Today) -- Investigational apitegromab -- a selective myostatin activation inhibitor -- effectively preserved lean mass when combined with tirzepatide (Zepbound) in a randomized phase II trial, suggesting it could help fight "Ozempic...
A new drug, called apitegromab, could be useful for preserving lean muscle mass during treatment with drugs such as tirzepatide. Read more at: https://www.elmundo.es/ciencia-y-salud/salud/2026/06/08/6a26a941e85ece4f618b4573.html Author: EL MUNDO Published: 2026-06-08 18:17:00 Copyright for syndicated content belongs to the linked source.
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