A closer look at Parkinson’s brains finds tau where standard tests saw little

A closer look at Parkinson’s brains finds tau where standard tests saw little

Researchers used single-molecule and super-resolution imaging to profile protein aggregates across six brain regions from 29 post-mortem donors, detecting high-intensity phosphorylated tau aggregates in the Parkinson’s disease putamen despite negligible conventional tau staining. PD cases with dementia showed greater tau burden than those without dementia, while the assay did not detect a PD-specific population of nanoscopic alpha-synuclein aggr…