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49ers DT James Thompson returns to limited work, while Nick Bosa, George Kittle remain limited
Thompson Jr. is the only 49ers player listed as questionable, while Alfred Collins is out for the season after a torn patellar tendon.
On Friday, the San Francisco 49ers open their 2026 season against the Los Angeles Rams at the Melbourne Cricket Ground, marking the NFL's first regular-season game in Australia with star defensive end Nick Bosa cleared to play.
While Bosa and tight end George Kittle are active, defensive tackle Alfred Collins is out for the season with a torn patellar tendon, and James Thompson Jr. remains questionable with a hamstring injury.
Head coach Kyle Shanahan confirmed the team must be mindful of workloads for returning players, stating, "They both look great but we've definitely got to be smart with that."
The Rams face roster challenges with defensive tackle Aaron Donald ruled out of the Australia matchup, leaving San Francisco to enter nearly at full strength for the historic contest.
Bosa expressed confidence in his readiness, declaring he is "100 percent ready to go for the first game" despite managing quad muscle atrophy during his ACL recovery.