Study reveals dynamic remodeling of genome architecture during brain aging

Study reveals dynamic remodeling of genome architecture during brain aging

Researchers have discovered that the human brain undergoes widespread age-related changes in genome regulation beginning in midlife that may help explain why aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's.

Resetting the body’s rhythm could protect the brain from Alzheimer’s

Researchers discovered that altering the body’s natural rhythm can help protect the brain from Alzheimer’s damage. By turning off a circadian protein in mice, they raised NAD+ levels and reduced harmful tau buildup. The findings suggest that adjusting the body’s clock may one day help prevent neurodegeneration.

MIND Diet May Offer Extra Brain Protection for People at Higher Alzheimer's Risk

The foods we eat may play an important role in keeping our brains healthy as we age. A new study suggests that one eating plan, known as the MIND diet, may be especially helpful for people who already have early biological signs linked to Alzheimer’s disease, even before memory problems appear. The study was led […] The post MIND Diet May Offer Extra Brain Protection for People at Higher Alzheimer’s Risk appeared first on Knowridge Science Repor…

Single-Cell Atlas Simultaneously Maps 3D Genome Architecture and DNA Methylation

Scientists at the Salk Institute and the Arc Institute, along with their collaborators, unveiled the first body-wide single-cell atlas of two major epigenetic systems: three-dimensional genome folding and DNA methylation, measured simultaneously in the same cells. The atlas spans 86,689 cells from 16 human tissues, revealing 35 major cell types and 206 subtypes, and is freely available online. The work is part of the National Institutes of Healt…

3D Genome Disruption in Alzheimer's Disease

A new study shows that 3D genome architecture is altered in prefrontal cortex cells of individuals with Alzheimer's disease.