Study identifies epigenetic patterns affecting insulin and glucagon production in type 2 diabetes

Epigenome map reveals how blood sugar-regulating cells change in type 2 diabetes

Researchers at Lund University in Sweden have carried out the most detailed mapping to date of the epigenome in the cells that regulate the body's blood sugar levels. The study, published in Nature Metabolism, shows how chemical changes to DNA affect both insulin-producing beta cells and glucagon-producing alpha cells—and how these patterns change in type 2 diabetes.

Study identifies epigenetic patterns affecting insulin and glucagon production in type 2 diabetes

Researchers at Lund University in Sweden have carried out the most detailed mapping to date of the epigenome in the cells that regulate the body's blood sugar levels.

Epigenetic Mapping in Pancreatic Cells Identifies New Diabetes Target

Researchers at Lund University in Sweden have conducted the first study looking at epigenetic changes associated with type 2 diabetes in alpha and beta pancreatic cells. Published today in Nature Metabolism, their findings show that the ONECUT2 gene plays a key role in the development of type 2 diabetes by altering insulin production.  “The study shows that many genes central to insulin and glucagon production are regulated by differences in DNA…