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Psilocybin Offers Fast-Acting Alternative to Traditional Antidepressants

The phase 2 trial found 53% of psilocybin patients were in remission after six weeks, compared with 6% in the placebo group.

Summary by News Medical
A single dose of the psychedelic substance psilocybin can provide rapid relief from depressive symptoms – within just a few days. This is shown by the first randomised, double-blind study in Sweden of psilocybin for depression. The effect persisted for over three months, according to researchers at Karolinska Institutet.

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People with recurrent depression experienced reduced symptoms for several weeks after treatment with psilocybin, in a small Swedish study.

·Falkenberg, Sweden
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Two days. That's how long it took psilocybin, in a study by the Karolinska Institutet, to reduce the symptoms of depression. Antidepressants require six weeks. Imagine: a whopping 53% of participants were in clinical remission at six weeks, compared to just 6% in the placebo group. Big numbers, until the one-year data arrived, and the story changed a bit. So, let's see: the study, published today in JAMA Network Open, is a Phase 2, randomized, a…

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Medical Xpress broke the news on Friday, May 15, 2026.
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