Shingles vaccine linked to 24% lower dementia risk
Among 509,926 nursing-facility residents, Shingrix recipients had an 18.8% dementia rate versus 24.6% for unvaccinated adults, researchers found.
- Researchers led by Kaley Hayes at Brown University found that nursing-facility residents receiving Shingrix had a 24% lower risk of dementia over four years, according to a study published yesterday in Annals of Internal Medicine.
- Using Medicare claims and records, researchers analyzed 509,926 people across more than 5,500 skilled nursing facilities between 2017 and 2022. Target trial emulation compared 8,843 residents who received at least one Shingrix dose against unvaccinated participants.
- After four years, dementia developed in 18.8% of vaccinated participants versus 24.6% of those unvaccinated. "This translates to about one in 17 dementia cases potentially being prevented," Hayes said.
- The findings align with earlier research suggesting shingles vaccines offer neuroprotective benefits beyond preventing shingles. Hayes noted the results fit into a larger puzzle showing vaccines support both physical and cognitive health.
- Researchers cannot definitively confirm Shingrix caused the lower dementia risk because vaccinated participants were younger and healthier. Hayes urged clinical trials to establish causation, and the study received funding from GlaxoSmithKline, which had no control over publication.
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Shingles vaccine linked to 24% lower dementia risk
Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people. Researchers estimate the difference could amount to roughly one dementia case prevented for every 17 people vaccinated.
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