New Metric Detects Early Alzheimer’s Changes in Brain White Matter
The plaques appeared in neurons and may emerge earlier than beta-amyloid, researchers said, pointing to new biomarker and treatment targets.
5 Articles
5 Articles
New metric detects early Alzheimer’s changes in brain white matter
Alzheimer's disease has traditionally been studied as a condition that primarily affects the brain's gray matter, where neuronal cell bodies are located and some of the disease's most characteristic lesions accumulate.
Mapping Amyloid-PET Uptake in the White Matter in Alzheimer’s Disease
Introduction Alzheimer’s disease (AD) is pathologically defined by amyloid-beta plaques and tau neurofibrillary tangles, but white matter (WM) alterations are also a feature whose contribution to the disease process remains poorly understood. Amyloid-PET tracers can show physiol...
A metric obtained with diffusion magnetic resonance imaging can detect microscopic alterations in the white matter of the brain in the early stages of Alzheimer's disease. This is indicated by a study by the Sant Pau Research Institute, which has analyzed both cases of sporadic Alzheimer's and people with Down syndrome. The measurement, called PSMD – English acronym for peak width of skeletonized mean diffusivity – has identified changes in peop…
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