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Scientists Discover Why We Know when to Stop Scratching an Itch

TRPV4 channels in sensory neurons both trigger itch and send a stop signal to reduce scratching, affecting chronic itch conditions like eczema in about 10% of U.S. people.

Summary by Medical Xpress
When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels "enough," is not accidental. Scientists have now identified a key molecular and neural mechanism behind this built-in braking system, shedding new light on how the body regulates itch and why this control fails in chronic conditions.

7 Articles

People who cannot stop scratching their itchings could finally have a culprit to blame. In mice (and probably in humans), a protein called TRPV4 is involved both in triggering itching and in stopping after scratching, explains neuroscientist Roberta Gualdani. She will present her results [...]

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Science News broke the news in United States on Saturday, February 21, 2026.
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