Reversing Radiation-Activated Immune Suppression in Cancer
5 Articles
5 Articles
Researchers at the U.S. University of Chicago have identified a molecular mechanism that could contribute to strengthening the immune system ' s capacity to control tumors after radiation treatment, by controlling proteins that play a role in regulating the functions of some immune cells, and that could drive them to reduce the immune response to cancer.
Medical Xpress
Reversing radiation-activated immune suppression in cancer
Researchers at the University of Chicago have identified a mechanism to make immune cells reprogrammed by radiation therapy attack tumors rather than protect them. The study, published in Cancer Cell, shows that radiation activates a protein called TET2 on immune cells in bone marrow, where it removes chemical tags from RNA and locks these cells into an immune-suppressing state.
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