US EditionPotential 'Holy Grail' Nasal Spray that May Protect Against COVID-19, Flu and Pneumonia Aims for Human Trials
The nasal vaccine mimics immune signaling to protect mice against COVID-19, flu, pneumonia, bacterial infections, and allergens for at least three months, researchers said.
- On Thursday, researchers at Stanford published in Science that a nasal spray protected mice against COVID-19, influenza, pneumonia, and dust-mite allergens.
- Because mice lungs are used as a model for testing protection, the vaccine mimics immune-cell signals rather than pathogens, according to the team.
- Authors described the result as nearing a universal vaccine, and study senior author Pulendran expects two doses would be needed in humans.
- Researchers plan human safety trials next, starting with a safety trial followed by larger studies, and say if validated in people, the approach would transform respiratory prevention.
- Researchers say a single nasal spray could soon protect people against respiratory viruses, bacteria and allergens, approaching the 'Holy Grail' of a universal vaccine.
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Potential 'holy grail' nasal spray that may protect against COVID-19, flu and pneumonia aims for human trials
Stanford's potential universal vaccine promises to shield against COVID, flu, and more. Could one spray change how we fight respiratory threats? (Adobe Photo)
Single vaccine could protect against all respiratory pathogens
Early research raised hopes for a vaccine that would protect against all respiratory pathogens simultaneously, rather than just a single disease such as influenza. Traditional vaccines prime the immune system for specific targets, such as a protein on a virus. The new system, delivered via nasal spray, boosts the system’s communication signals, putting it on a higher alert. In mice, the spray reduced infection rates from viruses including flu an…
U.S. researchers have reported successful results from mouse tests, raising many hopes Two simple sprays, and protection from an entire panel
American researchers have shown that drops protect mice from various infections for several months. An application in humans is a huge challenge.
Single vaccine could protect against all coughs, colds and flus, researchers say
(BBC) – A single nasal spray vaccine could protect against all coughs, colds and flus, as well as bacterial lung infections, and may even ease allergies, say US researchers. The team at Stanford University have tested their “universal vaccine” in animals and still need to do human clinical trials. Their approach marks a “radical departure” from the way vaccines have been designed for more than 200 years, they say. Experts in the field said the s…
Mucosal Vaccination in Mice Provides Protection from Diverse Respiratory Threats
Investigators described an intranasal liposomal formulation combining toll-like receptor 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus. [Science] Abstract
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