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Repeatedly losing and gaining weight may accelerate muscle loss

Researchers found weight cyclers lost about 3.7% of thigh muscle over four years, nearly four times more than people with stable weight.

Summary by News Medical
Repeatedly losing and gaining weight may do more than frustrate dieters - it also accelerates muscle loss in middle-aged people, according to new UC San Francisco research that comes as weight-loss medications transform obesity treatment.

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If the yo-yo effect is repeated, muscle mass may not recover even if weight returns to its original level. A study tracking 1,433 middle-aged individuals via MRI for four years has found that if the yo-yo phenomenon of losing and regaining weight is repeated, lost muscle mass may not be recovered even if body weight returns to its original level. Research by the University of California, San Francisco.

New research from scientists at the University of California, San Francisco, reveals previously unknown effects of repeated weight fluctuations, known as the yo-yo effect. The findings, published in the prestigious journal "Radiology," indicate that cyclical weight loss and weight gain, in addition to making it difficult to permanently lose excess weight, can—especially in middle-aged people—lead to a noticeable loss of muscle mass.

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Medical Xpress broke the news in Douglas, United Kingdom on Tuesday, July 21, 2026.
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