Psilocybin Reshapes Brain Connections Through Distinct Cellular Pathways

How psilocybin reshapes brain circuits

A new study led by researchers at the University of California, Santa Cruz, reveals how psilocybin, the psychoactive compound in "magic mushrooms," reshapes neural connections in the brain.

Psilocybin reshapes brain connections through distinct cellular pathways

A new study led by researchers at the University of California, Santa Cruz, reveals how psilocybin, the psychoactive compound in "magic mushrooms," reshapes neural connections in the brain.

Psilocybin Replaces Lost Synapses in Depressed Brains

Does healing the brain with psychedelics require a "trip"? A new study shows psilocybin drives synaptic plasticity through Layer 5 pyramidal neurons independently of hallucinogenic signaling, opening the door to non-hallucinogenic depression therapeutics.

Psilocybin rewires brain circuits through a pathway separate from

A UC Santa Cruz study in mice shows psilocybin rapidly forms and matures dendritic spines, selectively restores stress-damaged circuits, and acts through serotonin 2A receptors on layer 5 pyramidal neurons in a pathway separable from the hallucinogenic head-twitch response, suggesting a route to non-hallucinogenic psychiatric drugs.