Prostate Cancer Genomic Analysis Links Mutational Footprints to Clinical Outcomes
Researchers identified eight mutational footprints in nearly 1,000 tumors, and four were linked to faster spread and could help guide treatment choices.
- Researchers from the University of Copenhagen, along with OICR and BRIC, identified eight genetic fingerprints in Nature that account for 85 per cent of prostate cancer cases, enabling better tracking of disease development and identification of high-risk patients.
- DNA replication errors and hormone pathways drive these mutations, creating clinical outcomes ranging from indolent to lethal; these IMFs offer a new framework for understanding why prostate cancer progresses differently in men.
- Analyzing 959 prostate cancer tumor samples, the team found four IMFs present in 37% of primary tumors significantly associated with shorter time to metastasis, explaining the mutational processes driving clinical heterogeneity.
- Joachim Weischenfeldt said the eight signatures may help doctors determine whether patients respond to chemotherapy or need hormone therapy, adding, "Our goal is to tailor treatment to each individual patient's disease."
- More extensive prospective studies are needed to validate findings for clinical use, Weischenfeldt noted, explaining, "It is a bit like a crime scene," regarding how genetic signatures reveal disease processes.
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Unlike other cancers, this study highlights the absence of traces due to external factors, such as tobacco, suggesting that the damage comes mostly from internal biological mechanisms.
New genetic map helps track aggressive prostate cancer development
Prostate cancer is the second most common form of cancer among men globally. Yet, we still know relatively little about why the disease develops or why some men live with it for years while in others it progresses aggressively.
Madrid, 9 Sep (EFE).- An international team of researchers has managed to identify eight faulty cellular processes that explain the genetic damage responsible for 85 percent of prostate cancer cases. The work, which has been coordinated by researchers from the Spanish National Center for Oncological Research (CNIO) has been based on analysis [...] The entry Scientists discover the processes that damage DNA in most prostate cancers was first publ…
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