Persistent Gut Microbiome Changes Linked to Sustained Colorectal Cancer Risk

Persistent gut microbiome changes linked to sustained colorectal cancer risk

More than a decade after removal of an adenoma-a precancerous mass-from the colon, alterations to the gut microbiome and metabolites remain and may drive heightened risk of colorectal cancer (CRC), according to a new study led by researchers at Harvard T.H. Chan School of Public Health.

Colorectal Cancer Risk May Remain Higher Even After Polyp Removal, Study Suggests

Gut microbiome changes may help explain why colorectal cancer risk can remain higher even after precancerous colon polyps are found and removed, according to a new study.e60dc2a1-f33c-4a05-9b50-8e3e8e59762970056ec8-ec7d-4f51-ae68-4fc6f1ae6c83 Researchers found that people with a history of these polyps, called adenomas, still had differences in their gut bacteria and stool chemicals years later that resembled patterns seen in people with colorec…

Precancerous Adenomas Alter Gut Microbiome for Long Period

Research shows people who have precancerous polyps removed have an altered gut microbiome for around 12 years after undergoing surgery, which may explain why there is a significant risk of progressing to colorectal cancer in these individuals despite the surgery. “Early detection and resection of adenomas through colonoscopy are critical strategies for preventing colorectal cancer. However, individuals with a history of adenoma resection remain …