US EditionStudy Links High-Fat Diet to Faster Breast Cancer Progression
The high-fat diet increased the enzyme MMP1 linked to poor prognosis and had more impact on tumor growth than glucose, insulin, or ketones, researchers said.
- A multidisciplinary team at Princeton reported that a high-fat dietary condition accelerated tumor growth and invasion in triple-negative breast cancer, using engineered tumor models to study nutrient effects.
- In a human plasma-like medium, researchers engineered tumor models and tested four dietary states to replicate nutrient effects and isolate specific impacts on the tumor microenvironment.
- Molecular assays revealed the high-fat condition had stronger effects than glucose, insulin or ketone levels and raised MMP1, an enzyme linked to extracellular matrix degradation and poorer prognosis.
- The research team will test whether tumors respond differently to chemotherapy when cultured in media that mimic different dietary conditions, extending their findings to other breast cancer subtypes.
- Contrary to expectations, the team found the researchers' initial hypothesis failed as the high-fat diet accelerated tumor growth, challenging earlier studies examining diet-tumor links including immune system, metabolic tissues, and microbiome.
15 Articles
15 Articles
High-Fat Conditions Accelerate Invasion in 3D Model of Triple-Negative Breast Cancer
A new microfluidic study is offering fresh insight into how circulating nutrients may directly shape tumor behavior—without the confounding effects of the immune system, microbiome, or whole-body metabolism. In a paper published in ALP Bioengineering, co-first authors Maryam Kohram and Carolina Trenado-Yuste report that high-fat conditions accelerated growth and invasion in a three-dimensional (3D) microfluidic model of triple-negative breast ca…
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BIOENGINEER.ORGHigh-Fat Diet Promotes Rapid Breast Cancer Tumor Growth and Invasion
Emerging research from Princeton University is reshaping our understanding of dietary influence on breast cancer progression, particularly highlighting how a high-fat diet may exacerbate the growth and invasive capabilities of triple-negative breast cancer tumors. This groundbreaking study, recently published in APL Bioengineering, deploys a sophisticated in vitro tumor model that mimics the dynamic nutrient environment found in human plasma, of…
High-Fat Diet Accelerates Breast Cancer Tumor Growth and Invasion
A multidisciplinary team wanted to find the best diet to slow tumor growth after a breast cancer diagnosis. Instead, they found one that accelerated it: a high-fat diet. The researchers engineered a tumor model using a human plasmalike medium to re-create a more realistic microenvironment around tumors, and this allowed them to replicate the biochemical effects of nutrients from food. They discovered a high-fat diet accelerates tumor growth and …
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